Regulators of adipocyte precursor cells

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Regulators of adipocyte precursor cells.

Lean and adipose tissue growth are two of the most important targets for manipulation in commercial livestock. Adipose tissue growth occurs by both hyperplasia and hypertrophy. The processes involved in adipocyte hypertrophy are relatively well understood but much less is known about adipocyte hyperplasia. The mature adipocyte has little capacity for cell division and the hyperplastic capacity ...

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As well as being the precursors of the triacylglycerols deposited as fat in adipose tissue, long-chain fatty acids are one class of agents that induce the differentiation of preadipocytes to adipocytes.

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Emerging Roles of Cell Cycle Regulators in Adipocyte Metabolism

Cells can adapt their growth and metabolism to their needs and the extracellular signals they receive. Some stimuli, such as stress or nutrients, are not only proliferative but also metabolic signals, suggesting a close crosstalk between these two biological processes. Indeed, the response to a metabolic signal can require the activation of transcription factors and of signaling molecules that ...

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Hormonal regulation of the differentiation of rat adipocyte precursor cells in primary culture.

A reproducible cell culture system is described that allows the study of adipose conversion in fibroblast-like cells isolated by collagenase digestion of epididymal and perirenal adipose tissue from male rats weighing 70-200 g. Adipose conversion as measured by lipid accumulation and increase in glycerophosphate dehydrogenase (GPDH) activity during differentiation strongly depends on the densit...

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The increased incidence of obesity and metabolic disease underscores the importance of elucidating the biology of adipose tissue development. The recent discovery of cell surface markers for prospective identification of adipose precursor cells (APCs) in vivo will greatly facilitate these studies, yet tools for specifically targeting these cells in vivo have not been identified. Here, we survey...

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ژورنال

عنوان ژورنال: Poultry Science

سال: 1997

ISSN: 0032-5791

DOI: 10.1093/ps/76.1.118